Pathophysiology and urine markers of interstitial cystitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10633
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Furuta Akira 東京慈恵会医科大学, 医学部, 准教授 (90349613)
• Research Collaborator: YAMAMOTO Tokunori 名古屋大学, 医学系研究科, 特任教授 ; YOSHIMURA Naoki ピッツバーグ大学, 医学部, 教授 ; EGAWA Shin 東京慈恵会医科大学, 医学部, 教授 ; SUZUKI Yasuyuki 東京都リハビリテーション病院, 診療部, 副院長
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 間質性膀胱炎 / 過活動膀胱 / 尿中マーカー / 病態

Outline of Final Research Achievements

Chronic inflammatory condition seems to be a shared characteristic in patients with interstitial cystitis (IC) and overactive bladder (OAB). Thus, we measured forty inflammatory urine markers in IC patients with or without Hunner lesions (HIC and NHIC, respectively) and OAB patients.
VEGF, IL-1α, IL-6 and chemokines including CCL2, CCL5, CXCL1, CXCL8 and CXCL10 were significantly increased in HIC and NHIC patients compared with OAB patients. The significant increases in CXCL8 and CXCL10 were also found in HIC patients compared with NHIC patients. However, there were no significant differences in the other urine markers among the groups. Area under the curves for VEGF, CXCL10, CXCL8, IL-1α, CCL5, CCL2, IL-6 and CXCL1 to detect IC in these patients were 0.87, 0.86, 0.81, 0.80, 0.80, 0.71, 0.66 and 0.50, respectively.
In conclusion, the increases in angiogenesis-associated proteins such as VEGF and CXCL10 may pathophysiologically be important for the development of IC.

Free Research Field

排尿障害