overactive bladder & bladder sensation: a NIRS measurement

2019 Fiscal Year Final Research Report

• Project/Area Number: 15K10634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Toho University
• Principal Investigator: SAKAKIBARA Ryuji 東邦大学, 医学部, 教授 (00282476)
• Project Period (FY): 2015-04-01 – 2020-03-31
• Keywords: 過活動膀胱 / 膀胱感覚 / 知覚性尿意切迫 / 近赤外線分光法(NIRS)

Outline of Final Research Achievements

Using real-time near infrared spectroscopy (NIRS), we could elucidate the mechanism of bladder sensory abnormality in overactive bladder, bladder pain, neurogenic bladder dysfunction. We published the following manuscript in English.★Imidafenacin on bladder and cognitive function in neurologic OAB patients.Sakaibara R, Tateno F, Yano M, Takahashi O, Sugiyama M, Ogata T, Haruta H, Kishi M, Tsuyusaki Y, Yamamoto T, Uchiyama T, Yamanishi T, Yamaguchi C.
Clin Auton Res. 2013 Aug;23(4):189-95.★Fesoterodine normalizes the brain function in overactive bladder patients due to central nervous system lesion: A real-time measure of oxyhemoglobin concentration changes during urodynamics.Sakakibara R, Tateno F, Yano M, Takahashi O, Aiba Y, Yamamoto T.Int J Urol. 2019 Oct;26(10):1014-1015.

Free Research Field

脳神経内科学、泌尿神経学

Academic Significance and Societal Importance of the Research Achievements

NIRSの利点を用いて、従来明らかでなかった、過活動膀胱OAB、膀胱痛、神経因性膀胱などによる、膀胱知覚の異常をある程度解明できた。今後さらに、OAB、膀胱痛、神経因性膀胱が、重要な創薬ターゲットの一つとみなされていることから、上記の検討が、これらの疾患における治療薬開発、膀胱知覚異常の治療効果判定、に大きく活用できることが期待される。