2017 Fiscal Year Final Research Report
Prolongation of graft survival through peripheral tolerance mechanism via plasmacytoid dendritic cells
| Project/Area Number |
15K10649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 末梢性免疫寛容 / pDC |
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| Outline of Final Research Achievements |
The aim of this study is to investigate the mechanism of spontaneous tolerance in mice kidney transplantation. We employed the tolerance combination (group A: DBA→C57/BL6) and non-tolerance combination (group B: C3H→C57/BL6) and cocultured donor type plasmacytoid DC and recipient type naive T cells. The induction rate of Tregs were significantly higher in group A (10-15%) than in group B (3-5%). Significant prolonged heart allograft survival was observed in group A by administering co-cultured cells containing induced Tregs a week before transplant.
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| Free Research Field |
腎移植
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