Genomic imprinting in the human placenta

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10657
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: Okae Hiroaki 東北大学, 医学系研究科, 助教 (10582695)
• Co-Investigator(Kenkyū-buntansha): 有馬 隆博 東北大学, 医学系研究科, 教授 (80253532)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ゲノムインプリンティング / 胎盤 / 次世代シーケンサー / DNAメチル化 / 栄養膜幹（TS）細胞

Outline of Final Research Achievements

Genomic imprinting is essential for normal placental development. Here we conducted a genome-wide survey of imprinted genes in the human placenta and identified 44 novel imprinted genes. At least 27 of them were likely to be regulated by DNA methylation. Most of the novel imprinted genes were not imprinted in mouse or mule placenta, suggesting that genomic imprinting in the placenta is highly variable among mammalian species.

Free Research Field

分子生物学、エピジェネティクス