2017 Fiscal Year Final Research Report
Study on molecular mechanism of cervical maturation focusing on anti-protease system
| Project/Area Number |
15K10661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 子宮頸管熟化 / 抗菌ペプチド / 早産 / 炎症 |
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| Outline of Final Research Achievements |
This study aimed to investigate the molecular mechanism of cervical maturation focusing on secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-protease activity. In-vitro study and preterm birth mouse model demonstrated that SLPI at the cervix was induced by progesterone and inflammatory environment. SLPI administration inhibited the incidence of preterm birth in mice triggered by neutrophil elastase and LPS. In the analysis of cervical cells obtained from pregnant women, SLPI was elevated prior to the labor onset in both of term and preterm delivery. These findings suggested a critical role of SLPI in the regulation of cervical maturation prior to delivery.
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| Free Research Field |
産婦人科学
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