Could an appropriate antibiotic therapy improve neonatal outcome in preterm labor cases?

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10662
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: Yoneda Satoshi 富山大学, 附属病院, 講師 (30345590)
• Co-Investigator(Kenkyū-buntansha): 齋藤 滋 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 切迫早産 / 抗菌薬 / 羊水中微生物 / ウレアプラズマ / 子宮内炎症 / スラッジ

Outline of Final Research Achievements

Antibiotic therapy for preterm labor cases are effective for maternal infection, but it is rather worse for neonatal prognosis. However, intra-amniotic microbes are not evaluated.
A rapid and sensitive PCR system developped in our hospital could evaluate intra-amniotic microbes accurately. By using this PCR system, in positive-cases with intra-amniotic microbes, an appropriate antibiotic therapy could prolong the gestational days, whereas in negative-cases, an antibiotic had shortened the gestational period.
The intra-amniotic microbes should be detected accurately and an appropriate antibiotic therapy might be able to be a new strategy in management of preterm labor.

Free Research Field

切迫早産