Maintenance of germ cell quality via mitochondrial quality control

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Fukui
• Principal Investigator: ORISAKA Makoto 福井大学, 学術研究院医学系部門(附属病院部), 講師 (80324143)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Yasuyuki 独立行政法人国立がん研究センター, 腫瘍生物学分野, 主任研究員 (90569063)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 精子 / 卵子 / ミトコンドリア / 酸化ストレス / 加齢

Outline of Final Research Achievements

The present study demonstrates that mitochondrial quality control system plays an important role to maintain sperm quality. The failure of the mitochondrial quality control system with aging seems to induce oxidative stress in sperm, resulting poor sperm quality and poor embryo quality. On the contrary, the mitochondrial quality control system is not involved in poor oocyte quality with aging.

Free Research Field

生殖医学