2017 Fiscal Year Final Research Report
Basic examination for the development of the cure for embryo development disorder due to ooplasm abnormality
| Project/Area Number |
15K10664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
平田 修司 山梨大学, 大学院総合研究部, 教授 (00228785)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ミトコンドリア分布 / 紡錘体移植 / 胚発生 |
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| Outline of Final Research Achievements |
In aged oocyte, low developmental rate was reported to be associated with mitochondrial abnormal distribution. Thus using the metaphase II spindle injection (MESI) method, we investigate the relationship between the spindle and mitochondrial distribution in the murine MII oocyte. The MII spindle might be a determination factor of the mitochondrial distribution in the fresh MII ooplasm, but mitochondria were no longer redistributed in the 1-day-old ooplasm, implying that the redistribution potential of mitochondria might be related to the function of the MII oocyte.
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| Free Research Field |
婦人科腫瘍学
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