In utero Immune tolerance induction for Severe Congenital skin diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10669
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: ENDO MASAYUKI 大阪大学, 医学系研究科, 講師 (30644794)
• Co-Investigator(Kenkyū-buntansha): 玉井 克人 大阪大学, 医学系研究科, 寄附講座教授 (20236730) ; 冨松 拓治 大阪大学, 医学(系)研究科(研究院), 講師 (30346209) ; 味村 和哉 大阪大学, 医学(系)研究科(研究院), 助教 (50437422)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胎児治療 / 免疫寛容 / 幹細胞 / 移植 / マイクロキメリズム

Outline of Final Research Achievements

Induction of immunological reactions is a major problem in replacement therapies for inherited protein deficiencies. Tolerance created in utero can facilitate postnatal treatment. In this study, we show that cell transplantation into the chorionic villi under ultrasound guidance in the earliest gestation can induce immune tolerance towards a foreign protein within rodent models.

Free Research Field

胎児治療