2017 Fiscal Year Final Research Report
The mechanism of diminished ovarian reserve caused by pelvic inflammation and endmetriosis.
| Project/Area Number |
15K10674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
カーン カレク 京都府立医科大学, 医学研究科, 准教授 (60336162)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 子宮内膜症 / 骨盤内炎症 / 卵巣予備能 / 腹水 / サイトカイン / ケモカイン / プロゲスチン |
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| Outline of Final Research Achievements |
Surgery for endometriomas may cause significant decline in serum AMH levels, ovarian reserve maker, just after the surgery and it may increase soon after primary decline, and then decrease again till steady levels at around one year after the surgery. The time points when one measure serum AMH levels to evaluate the effect of surgery on ovarian reserve is important.
Three step surgery utilizing dienogest may show less decline in serum AMH levels. Progestin may affect intraperitoneal pro-inflammatory cytokines and chemokines, such as IL-6, IL-8, and IP-10. IP-10 can be a marker for anti-inflammatory effects of progestins.
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| Free Research Field |
生殖内分泌
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