Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Niigata University
• Principal Investigator: YAMAGUCHI Masayuki 新潟大学, 医歯学総合病院, 講師 (20529771)
• Co-Investigator(Kenkyū-buntansha): 吉原 弘祐 新潟大学, 医歯学系, 助教 (40547535) ; 関根 正幸 新潟大学, 医歯学総合病院, 助教 (70345502) ; 榎本 隆之 新潟大学, 医歯学系, 教授 (90283754)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミュラー管由来類内膜腺癌 / 類内膜癌関連遺伝子

Outline of Final Research Achievements

Microarray analyses were performed between uterine corpus endometrioid adenocarcinoma group (n=73), uterine corpus serous adenocarcinoma group (n=12), ovarian endometorioid adenocarcinoma group (n=20), and ovarian serous adenocarcinoma group (n=243). Consequently, 135 genes associated with ovarian endometorioid adenocarcinoma and 102 genes associated with uterine corpus endometrioid adenocarcinoma were extracted. We compared gene expression profiling of ovarian endometrioid adenocarcinoma with that of uterine corpus endometrioid adenocarcinoma and validated reproducibility using TCGA database. Finally, difference in degree of PI3K-AKT pathway activation between ovarian endometrioid adenocarcinoma and uterine corpus endometrioid adenocarcinoma was revealed with single sample gene set enrichmint analysis.

Free Research Field

婦人科腫瘍