The endocrinological contribution to the novel strategy of endometrial cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10723
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kumamoto University
• Principal Investigator: Saito Fumitaka 熊本大学, 医学部附属病院, 助教 (20555742)
• Co-Investigator(Kenkyū-buntansha): 田代 浩徳 熊本大学, 大学院生命科学研究部(保), 教授 (70304996) ; 片渕 秀隆 熊本大学, 大学院生命科学研究部(医), 教授 (90224451)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 子宮内膜癌 / 内分泌学

Outline of Final Research Achievements

Obesity and diabetes have been reported to increase the risk for endometrial carcinoma. On the analysis of the endocrine profiles in these patients, we focused our attention on the existence of patients with high serum prolactin (PRL) levels. We investigated the contribution of PRL to the endometrial carcinogenesis. Although the patients with hyperprolactinemia presented the same characteristics as those of endometrial carcinoma, PTEN mutations were detected in a small proportion. PRL might be involved in endometrial carcinogenesis via another molecular alteration.
We investigated the endocrinological contribution to the enhanced response to MPA in endometrial cancer. In MPA treatment for early endometrial cancer, improvement of IR and hyperprolactinemia can be expected to result in favorable outcomes.

Free Research Field

婦人科腫瘍学