Estrogen-related receptor alpha as a potential target for endometrial cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10726
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Mori Taisuke 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00569824)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 子宮体癌 / ホルモン依存性腫瘍

Outline of Final Research Achievements

The elevated levels of ERRa was associated with advanced clinical stages and serous histological type. ERRa demonstrated negative prognostic significance. Knockdown of ERRa suppressed angiogenesis via VEGF, inhibited cell proliferation and induced cell cycle arrest at the mitotic phase and caspase-3 dependent apoptosis. A significant reduction of tumor growth and angiogenesis was observed in xenografts with ERRa knockdown. We propose that ERRa can serve as a novel target for molecular therapy of endometrial cancer.

Free Research Field

婦人科腫瘍学