Mucosal regenerative medicine for middle ear by using cell sheet technology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10766
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Hiromi Kojima 東京慈恵会医科大学, 医学部, 教授 (60234762)
• Co-Investigator(Kenkyū-buntansha): 和田 弘太 東邦大学, 医学部, 教授 (20307482) ; 山本 和央 東京慈恵会医科大学, 医学部, 助教 (50408449)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 中耳粘膜 / 粘膜再生 / 細胞シート / 中耳真珠腫 / 癒着性中耳炎 / 温度応答性培養皿 / 再生医療 / 鼻腔粘膜

Outline of Final Research Achievements

The recurrence of cholesteatoma and re-adhesion of the tympanic membrane are often occurred after conventional tympanoplasty. Although regenerated middle ear mucosa plays a key role in prevention of recurrence, much of mucosa is lost in the process of the tympanoplasty. To overcome this problem, we considered that the middle ear mucosa can be regenerated rapidly, the results of treatment can potentially be improved.
After basic research, we developed a novel regenerative medicine combining tympanoplasty and autologous nasal mucosal epithelial cell sheet transplantation for regeneration of the middle ear. We performed this procedure on seven patients with middle ear cholesteatoma and three patients with adhesive otitis media in this study. All patients showed favorable postoperative course with no adverse events or complications and the patients’ hearing ability post-transplantation remained good.

Free Research Field

耳科学