2017 Fiscal Year Final Research Report
Development of new treatments for chronic rhinosinusitis
Project/Area Number |
15K10777
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | Yamagata University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
鈴木 祐輔 山形大学, 医学部, 助教 (50466629)
千葉 真人 山形大学, 医学部, 非常勤講師 (80594324)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | ペリオスチン / 慢性副鼻腔炎 / 鼻ポリープ |
Outline of Final Research Achievements |
Several factors contribute to pathologies such as excessive mucus production and mucosal edema, leading to nasal discharge and obstruction in inflammatory nasal disorders. To assess the correlation between expression level of periostin and allergic inflammation, we investigated nasal polyps of eosinophilic chronic rhinosinusitis patients by immunohistochemistry. It was revealed that periostin expressed in subepithelial stroma layer of nasal polyp regardless of allergic inflammation or not.
|
Free Research Field |
耳鼻咽喉科学
|