2017 Fiscal Year Final Research Report
Mechanism of production and release of tissue plasminogen activator in airway epithelial cells
| Project/Area Number |
15K10779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高林 哲司 福井大学, 学術研究院医学系部門(附属病院部), 講師 (70397272)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 鼻ポリープ / t-PA / レチノイン酸 |
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| Outline of Final Research Achievements |
We have evaluated patients with AERD had even lower levels of RA in their nasal polyp tissue compared with CRSwNP. It is tempting to speculate that RA might be necessary for basic production and secretion of t-PA and may regulate fibrin deposition in normal tissue. We have studied the regulation of t-PA production in airway epithelial cells by cytokines and retinoic acid, a topic not researched ever. Retinoic acid, an active metabolite of vitamin A, induced a dose dependent increase of t-PA expression by NHBE cells; most t-PA produced was released into the supernatant. We confirmed the previous finding that IL-13 suppresses t-PA expression and have also shown that RA can restore t-PA expression in IL-13-treated cells. Finally, our results suggest that supplementation of polyposis patients with retinoids might shrink polyps or prevent recurrence of polyps after surgery by inducing t-PA and promoting degradation of fibrin deposited within polyps.
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| Free Research Field |
鼻・副鼻腔疾患
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