2017 Fiscal Year Final Research Report
Role of cellular arrangement in the olfactory epithelium
| Project/Area Number |
15K10782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TOGASHI Hideru 神戸大学, 大学院医学研究科, 助教 (90415240)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 嗅上皮 / 接着分子 |
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| Outline of Final Research Achievements |
In the olfactory epithelium, olfactory cells (OCs) and supporting cells (SCs) are arranged in a characteristic mosaic pattern, where OCs are separated each other and surrounded by SCs. The cellular pattern is established by cellular rearrangement during development. However, the mechanisms underlying this cellular rearrangement was unclear. In the olfactory epithelium, OCs express nectin-2 and N-cadherin, and SCs express nectin-2, necitn-3 and E-cadherin. Heterophilic trans-interaction between nectin-2 on OCs and nectin-3 on SCs recruits N-cadherin via alpha-catenin to the heterotypic junctions, and differential distribution of cadherins between junctions promote cellular intercalations, resulting in the formation of the mosaic pattern. These results suggest the possibility that synergistic action of nectins and cadhrins contributes to various complex cellular patterning, which cannot be achieved by a single mechanism.
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| Free Research Field |
耳鼻咽喉科
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