Investigation of markers for diagnosis, recurrence and malignant transformation in inverted papilloma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Hasegawa Masahiro 琉球大学, 医学(系)研究科(研究院), 非常勤講師 (10347156)
• Co-Investigator(Kenkyū-buntansha): 真栄田 裕行 琉球大学, 医学(系)研究科(研究院), 准教授 (40264501) ; 山下 懐 琉球大学, 医学(系)研究科(研究院), 助教 (60569622)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 内反性乳頭腫 / 診断 / 再発 / 悪性化 / ヒト乳頭腫ウイルス / 扁平上皮癌抗原

Outline of Final Research Achievements

Squamous cell carcinoma antigen was significantly elevated in inverted papilloma than squamouse cell carcinoma (SCC)and infectious diseases (CRS). Higher viral loads and integration observed in the IP, IP+SCC, and SCC groups.In addtion,an inverse correlation between HPV presence and positive pRb indicated that persistent infection and integration play a part in tumorigenesis and malignant transformation in certain IP cases.Regardless of HPV status, p16INK4a positivity was frequently detected in IP cases (82.4%), less in SCC (12.5%) cases, and was not detected in the CRS group.

Free Research Field

耳鼻咽喉科