2017 Fiscal Year Final Research Report
New treatment strategy for allergic diseases by targeting blood type 2 follicular helper T cells and regulatory B cells
| Project/Area Number |
15K10787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIMIYA Shingo 札幌医科大学, 医学部附属フロンティア医学研究所・免疫制御医学部門, 教授 (30305221)
HIMI Tetsuo 札幌医科大学, 耳鼻咽喉科, 教授 (90181114)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 濾胞ヘルパーT細胞 / Tfh2細胞 / シラカバ花粉症 / アレルギー性鼻炎 / ICOS |
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| Outline of Final Research Achievements |
We analyzed lymphocytes in blood from patients with birch pollen allergy. The percentage of circulating Tfh2 cells in blood from patients with birch pollen allergy during the non-pollen season was increased compared with that in blood from healthy volunteers. We also found that the percentage of ICOS+ Tfh cells in blood from patients with birch pollen allergy increased during the pollen season and decreased during the non-pollen season. The percentage of circulating ICOS+ Tfh cells in blood from patients with birch pollen allergy was positively correlated with total symptom scores and level of birch-specific serum IgE. In addition, an increase in Bet v1-specific MHC class 2 tetramer-positive and ICOS+ Tfh cells was seen in patients with birch pollen allergy during the pollen season. The results suggest that elevated circulating Tfh2 cells reflect an allergic predisposition and that birch-specific and ICOS+ Tfh cells play an important role in the pathogenesis of birch pollen allergy.
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| Free Research Field |
免疫・アレルギー
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