Analysis of gene polymorphisms related to drinking and smoking in head and neck cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10814
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: Yamashita Yukashi 琉球大学, 医学(系)研究科(研究院), 助教 (60569622)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 頭頸部癌 / アルコール代謝遺伝子 / たばこ代謝遺伝子 / 遺伝子多型

Outline of Final Research Achievements

We examined genetic polymorphisms of alcohol metabolism genes ADH1B, ALDH2 and tobacco metabolism genes CYP1A1 MSP I, CYP1A1 Ile 462 Val, GSTM 1, GSTT 1, and GSTP 1 of 29 cases of laryngeal cancer, 67 cases of hypopharyngeal cancer, 123 cases of control group. Genetic polymorphisms with low alcohol metabolism of ADH1B * 1 / * 1 and ALDH2 * 1 / * 2 are risk factors (OR=5.84, OR=9.22) in hypopharyngeal cancer. Genetic polymorphisms with low tobacco metabolism of GSTM1 null is risk factor (OR=3.26) in laryngeal cancer. It was found that there was a difference in polymorphism which is a risk factor in hypopharyngeal cancer and laryngeal cancer.

Free Research Field

耳鼻咽喉・頭頸部外科