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2017 Fiscal Year Final Research Report

The expression levels of Lysophosphatidic asid receptors in head and neck squamous cell calcinoma.

Research Project

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Project/Area Number 15K10815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Matayoshi Sen  琉球大学, 医学部附属病院, 助教 (60448587)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsリゾホスファチジン酸 / LPA / 頭頸部癌 / Gタンパク共役受容体
Outline of Final Research Achievements

Lysophosphatidic acids(LPAs) have been implicated in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). We investigated the mRNA expression levels of LPA receptors(LPA1-6), LPA producing enzyme(Autotaxin;ATX) ,and LPA degrading enzyme(ACP6) in HNSCC samples. The expression levels of LPA1 in hypophalynageal carcinoma(HPC) was eight times higher than that of LPA4. Further more, HPC showed high expression level of ATX. Our data suggest that the difference of LPA1 and LPA4 expression may influences malignant beahviors of HNSCCs.

Free Research Field

耳鼻咽喉科

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Published: 2019-03-29  

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