Development of photodynamic therapy on age-related macular degeneration based on abnormally-aggregated proteins.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Tsukuba
• Principal Investigator: KAJI YUICHI 筑波大学, 医学医療系, 准教授 (50361332)
• Research Collaborator: KANO Hideaki 筑波大学, 数理物質系, 准教授 (70334240)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: 加齢黄斑変性 / アミロイドβ / 蛋白糖化最終産物 / 右手型アミノ酸 / 光線力学療法 / 光感受性物質

Outline of Final Research Achievements

Abnormally aggregated proteins including amyloid-b is detected in age-related macular degeneration. We found increased concentration of autoantibodies to racemized or advanced glycated amyloid-b. Racemaized and advanced glycated amyloid-b peptide showed increased aggregation to form oligomer or polymer in vitro. Using thioflavin-T as photosensitized reagent, we successfully destroy aggregated form of amyloid-b. These results have become a molecular basis of photodynamic therapy on age-related macular degeneration.

Free Research Field

眼科学