2017 Fiscal Year Final Research Report
Investigation of the onset mechanism of primary open-angle glaucoma -Genetic investigation of the mechanism of intraocular pressure elevation-
| Project/Area Number |
15K10861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MABUCHI Fumihiko 山梨大学, 大学院総合研究部, 医学研究員 (20322125)
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| Co-Investigator(Kenkyū-buntansha) |
柏木 賢治 山梨大学, 大学院総合研究部, 准教授 (30194723)
櫻田 庸一 山梨大学, 大学院総合研究部, 講師 (90456476)
米山 征吾 山梨大学, 大学院総合研究部, 助教 (90751652)
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| Research Collaborator |
KUWABARA Ryoko
YOSHIZAWA Satoko
MABUCHI Nakako
KUME Atsuki
IIJIMA Hiroyuki
YAMAGATA Zentaro
TAKMOTO Mitsuko
AIHARA Makoto
IWATA Takeshi
SHIGA Yukihiro
NISHIGUCHI Koji
NAKAZAWA Toru
KAWASE Kazuhike
OZAKI Mineo
ARAIE Makoto
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 原発開放隅角緑内障 / 遺伝子多型 / 眼圧 / POAG / IOP / NTG / HTG / VCDR |
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| Outline of Final Research Achievements |
This study was performed to investigate the association between the additive effects of intraocular presure (IOP)-related genetic variants and maximum IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of POAG. As the total number of risk alleles of IOP-related genetic variants increased, the maximum IOP and VCDR significantly increased. The IOP and VCDR were increased by the additive effects of IOP-related genetic variants in POAG, and the phenotype (HTG or NTG) in POAG depends on the additive effects of IOP-related genetic variants.
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| Free Research Field |
眼科学 緑内障 人類遺伝学
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