Elucidation of a destruction mechanism and development of new treatment on intraocular chronic inflammatory diseases with CYP metabolites

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10869
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yamaguchi University
• Principal Investigator: YANAI Ryoji 山口大学, 医学部附属病院, 講師 (10346554)
• Co-Investigator(Kenkyū-buntansha): 園田 康平 九州大学, 医学研究院, 教授 (10294943) ; 佐古田 幸美 山口大学, 大学院医学系研究科, 講師 (30629754) ; 折田 朋子 山口大学, 医学部附属病院, 助教 (50467792) ; 木村 和博 山口大学, 大学院医学系研究科, 教授 (60335255) ; 寺西 慎一郎 山口大学, 医学部附属病院, 助教 (90649360)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 眼炎症 / 加齢黄斑変性症 / ぶどう膜炎 / オメガ3脂肪酸 / チトクロームP

Outline of Final Research Achievements

We demonstrate that dietary supplementation of ω-3 LCPUFAs mediate choroidal neovessel regression with leukocyte recruitment and inflammatory reduction in choroidal neovascular lesions. Furthermore, we show that a diet enriched in ω-3 LCPUFAs suppressed uveitis in mice in association with inhibition of Th1 and Th17 cell function. cytochrome P450 (CYP) epoxygenases target the ω-3 double bond, resulting in an accumulation of 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) derived from EPA, one of major ω-3 LCPUFAs.
In current study, we examined the anti-inflammatory properties of these molecules and have shown that 17,18-EEQ suppressed intraocular inflammation, as evaluated both clinically and histologically, in mice with EAU by inhibiting both systemic and retinal Th1 and Th17 cells.

Free Research Field

眼科学