2019 Fiscal Year Final Research Report
The role of desmosomes and intermediate diameter filament-related factors in the corneal epithelium
| Project/Area Number |
15K10876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
雑賀 司珠也 和歌山県立医科大学, 医学部, 教授 (40254544)
岡田 由香 和歌山県立医科大学, 医学部, 准教授 (50264891)
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| Project Period (FY) |
2015-04-01 – 2020-03-31
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| Keywords | 創傷治癒 / 角膜上皮 |
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| Outline of Final Research Achievements |
Knockdown of EPPK with siRNA in cultured corneal epithelial cells suppressed E-cadherin expression and promoted migration and proliferation. The result that down-regulation of EPPK accompanied by down-regulation of E-cadherin expression promoted epithelial cell migration is a common molecular kinetics of epithelial-mesenchymal transition (EMT) of epithelial cells, which is largely related to cancer cell invasion.
Corneal epithelium-specific plakoglobin (JUP) deficient mice were cross created from Cre recombinase-expressing mice and JUP flox/flox mice and reported corneal epithelial fragility and delayed wound healing.
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| Free Research Field |
創傷治癒
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| Academic Significance and Societal Importance of the Research Achievements |
角膜特異的JUP欠損マウスでの角膜上皮の脆弱性が示されたことから細胞骨格や細胞間接着の障害が想定された。JUP遺伝子異常症例のNaxos病ではNaxos病という，エーゲ海・Naxos島の風土病として知られ，手掌などの角化症とwoolly hairという特徴的な髪の毛の異常を合併する病気があることがギリシャのProtonotarios博士らにより報告されているが、不整脈以外に眼科診療も重要であると考えられた。
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