2017 Fiscal Year Final Research Report
Approach for retinal diseases based on regulation of hypoxia response
| Project/Area Number |
15K10881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 網膜 / 低酸素応答 / 動物モデル / 薬物治療 |
|---|
| Outline of Final Research Achievements |
To date, hypoxia-inducible factors (HIFs) have been revealed to play an important role in pathogenesis of various diseases. In this study, we generated and evaluated conditional knockout mice for HIFs and their negative regulator VHL. HIF deletion in adult retina induced no abnormal phenotype whereas ectopic HIF stabilization lead retinal degeneration indicating that HIF can be a new therapeutic target for retinal diseases. Furthermore, we administrated HIF inhibitors in animal models of retinal degeneration and confirmed a therapeutic effect against the phenotypes. These results suggested that HIF inhibition can contribute not only for retinal disease treatment but also prevention.
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| Free Research Field |
眼科学
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