The effect of corneal and conjunctival epithelial wound healing through the parasympathetic nerve protection and repairing by neurotropic factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Juntendo University
• Principal Investigator: Toshida Hiroshi 順天堂大学, 医学部, 先任准教授 (00306961)
• Co-Investigator(Kenkyū-buntansha): 須藤 史子 東京女子医科大学, 医学部, 准教授 (30246467) ; 藤巻 拓郎 順天堂大学, 医学部, 非常勤講師 (50333042)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 副交感神経 / ドライアイ / 角結膜上皮 / 涙腺 / 除神経

Outline of Final Research Achievements

Lacrimation from main lacrimal gland (LG) is mainly innervated by parasympathetic nerve. Injury of the nerve leads to decrease tear flow and damage in corneal and conjunctival epithelia. We have studied possibility that recovering from decreased tear fluid secretion and corneal and conjunctival epithelia through regeneration of the nerve using a parasympathetic denervated rabbit model.
Retrograde dye tracing study was performed to confirm that the most innervated ganglia was the pterygopalatine ganglion in parasympathetic nervous system on the same side.
As glial cell line-derived neurotrophic factor (GDNF), one of neurotropic factor, we have treated with GDNF in the surgical area, but few remarkable change were shown in the tear fluid secretion and a corneal and conjunctival findings.

Free Research Field

眼科学