New biomarkers of pediatric inflammatory bowel disease using proteomics

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10920
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Mie University
• Principal Investigator: Uchida Keiichi 三重大学, 医学部附属病院, 准教授 (30293781)
• Co-Investigator(Kenkyū-buntansha): 井上 幹大 三重大学, 医学部附属病院, 講師 (30422835) ; 大竹 耕平 三重大学, 医学系研究科, リサーチアソシエイト (40378344) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 潰瘍性大腸炎 / バイオマーカー / microRNA

Outline of Final Research Achievements

Protein was extracted from intestinal mucosa specimens of pediatric ulcerative colitis, and biomarkers related to diagnosis and severity were searched using proteomics. However, the amount of protein extracted from the mucosa was insufficient and no effectiveness was found. Therefore, we measured the methylation of age-related microRNA and clarified that the methylation level of miR-124 and miR-137 correlates with age and duration of disease and it can be a biomarker of colitic cancer.

Free Research Field

小児炎症性腸疾患