Evaluation of serum TARC (CCL17) as an immune suppression maker for pediatric liver transplantation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10925
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Kyushu University
• Principal Investigator: Esumi Genshiro 九州大学, 医学研究院, 共同研究員 (30452759)
• Co-Investigator(Kenkyū-buntansha): 松浦 俊治 九州大学, 医学研究院, 講師 (10532856) ; 林田 真 九州大学, 医学研究員, 共同研究員 (70452761) ; 田口 智章 九州大学, 医学研究院, 教授 (20197247)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: TARC / 移植 / 免疫抑制マーカー

Outline of Final Research Achievements

The aim of this study is to evaluate serum TARC measurement as immune suppression marker for solid organ transplantation recipients. Trough of FK-506, which is indirect marker and now widely used, do not directly indicate immune suppression statues, and sometimes it is not easy to keep and control immune suppression status in desirable level. In this research, serum TARC level partially correlate graft rejection and auto immune hepatitis episodes, but more correlate with their dermatitis. The validity of using TARC for immune suppression marker was concluded to be limited.

Free Research Field

固形臓器移植