2017 Fiscal Year Final Research Report
Development of new therapy of protracted refractory skin ulcer by using micro biome
| Project/Area Number |
15K10941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
Hideki Mori 愛媛大学, 医学系研究科, 助教 (60325389)
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| Co-Investigator(Kenkyū-buntansha) |
中岡 啓喜 愛媛大学, 医学部附属病院, 准教授 (30172266)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | マイクロバイオーム / HMGB1 |
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| Outline of Final Research Achievements |
S. epidermidis inhibited production of inflammatory cytokines induced by s. aureus in keratinocyte. High Mobility Group Box 1(HMGB1), which is one of nuclear protein, was strongly expressed in abscess of mouse ear induced by s. aureus, but not by s. epidermidis. Poly(I:C), which is synthesized dsRNA, induced inflammatory cytokines in keratinocyte. We found that reduced-HMGB1 suppressed poly(I:C) induced inflammation in keratinocyte.
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| Free Research Field |
皮膚の免疫
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