2017 Fiscal Year Final Research Report
MicroRNA and macrophage dysregulation: role in prolonged inflammation of chronic non-healing wounds
| Project/Area Number |
15K10943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | microRNA / 創傷治癒 |
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| Outline of Final Research Achievements |
This research project focused on deciphering the role of microRNA and macrophage dysregulation in prolonged inflammation phase of non healing chronic wounds. Employing mouse macrophage cells, we confirmed a set of inflammation-related microRNAs that are dysregulated in hypoxia condition. Among them, miR-21 was profound and induced prolongation of inflammatory phase. miR-21 was found to be necessary for RANKL-induced differentiation of macrophages into osteoclast cells. This function was inhibited by aloin, a derivative of aloe.
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| Free Research Field |
分子細胞生物学
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