2017 Fiscal Year Final Research Report
Novel regenerative skin reconstruction with dedifferentiated fat (DFAT) cells
| Project/Area Number |
15K10954
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
樫村 勉 日本大学, 医学部, 助教 (20570740)
松本 太郎 日本大学, 医学部, 教授 (50366580)
仲沢 弘明 日本大学, 医学部, 教授 (60180270)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 脱分化脂肪細胞 / 自家培養表皮 / 人工真皮 / 基底膜 |
|---|
| Outline of Final Research Achievements |
In Japan, a cultured epithelial autograft (CEA) was approved in 2009 by the public health insurance system for use in treatment of patients with severe burns. Wound bed preparation was performed with cryopreserved cadaver allograft skin or artificial dermis prior to CEA, because the CEA “take” rate on full-thickness skin defects without a dermal structure is poor.
Cultured epithelium takes due to formation of a basement membrane between the epidermis and dermis, basement membrane protein such as collagen IV or laminin-5 are essential for epithelial attachment to the dermis.
Treatment of AD (artificial dermis) with DFAT (dedifferentiated fat) cells promotes post-CEA production and deposition of laminin-5 at the dermal-epidermal junction and development of BM together with anchoring fibrils.
|
| Free Research Field |
形成外科
|
