Novel cancer immunotherapy: Application of Immuno-flap

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10963
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Jichi Medical University (2016-2017); Shizuoka Cancer Center Research Institute (2015)
• Principal Investigator: Inoue Keita 自治医科大学, 医学部, 非常勤講師 (80618520)
• Co-Investigator(Kenkyū-buntansha): 中川 雅裕 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (00285793) ; 三枝 紀子 (財)冲中記念成人病研究所, その他部局等, 研究員 (10642639) ; 秋山 靖人 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (70222552)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 免疫療法 / 樹状細胞 / 皮弁 / リンパ管

Outline of Final Research Achievements

The conceptual "immunologically augumented skin flap (immuno-flap)" is a novel anti-cancer approach, in which ant-cancer immunity is evoked by injection of dendritic cells stimulated by tumor specific antigens. The immuno-flap has been proved to be affective in a rat model so far. In this project,2015-2017,rat and porcine models were utilized to analyze to the traffics of GFP labeled cells and anatmy of lymphatic channels, suggesting porcine model was useful to examine the anti-cancer effect by immuno-flap.

Free Research Field

形成外科学