2017 Fiscal Year Final Research Report
Investigating the changes in anti-coagulation ability in vascular endothelial cells during acute phase traumatic coagulopathy
| Project/Area Number |
15K10964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 播種性血管内凝固 / 外傷 / 凝固障害 / 血管内皮細胞 / トロンボモジュリン |
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| Outline of Final Research Achievements |
In the present study, we tried to histologically elucidate the changes in thrombomodulin and glycocalyx in vascular endothelial cells. However, we could not detect significant changes in thrombomodulin and glycocalyx in vascular endothelial cells in DRAM-shock rat models. In these rat models, we identified microparticles, which activate the coagulation cascade, in the systemic circulation. Furthermore, the amounts of these microparticles were correlated with the severity of trauma.
Based on these findings, I formulated manuscripts using clinical data. Furthermore, I am currently formulating a manuscript based on the present study.
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| Free Research Field |
播種性血管内凝固
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