2017 Fiscal Year Final Research Report
A novel strategy of acute lung injury: Targeting sphingolipid signaling
| Project/Area Number |
15K10970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kawasaki Medical School (2016-2017)
Kanazawa University (2015) |
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Principal Investigator |
Okamoto Yasuo 川崎医科大学, 医学部, 教授 (80293877)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | スフィンゴシン1-リン酸 / 急性肺損傷 |
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| Outline of Final Research Achievements |
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator and plays an important role in the regulation of vascular barrier function. In this study, we found that S1P2 mediates the protection from acute lung injury possibly through inhibiting endothelial nitric oxide synthase, pointing to S1P2 as a promising novel target for treating acute lung injury.
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| Free Research Field |
脂質生物学
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