Evaluation of organ remodeling in severe sepsis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K10985
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: University of Miyazaki
• Principal Investigator: Yano Takeshi 宮崎大学, 医学部, 講師 (80521707)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 敗血症

Outline of Final Research Achievements

Sepsis is a condition that exhibits organ dysfunction due to poor control of host biological response to infection. In recent years, multidisciplinary treatment based on effective guidelines has been applied, short-term treatment outcomes are improving, but as a result of prolonged systemic dysfunction, long-term prognosis remains poor. In this experiment, we investigated the suppression effect of the recombinant thrombomodulin (rTM), which has a strong anti-inflammatory effect, for the prolonged vascular dysfunction in sepsis, the suppression of vascular endothelial dysfunction, and the effect on the recovery phase. When rTM was added, there was a tendency to suppress the prolongation of vasoconstriction degradation caused by lipopolysaccharide (LPS). Although LPS strongly injured vascular endothelial cells, rTM showed a tendency to maintain the tissue structure without association in the occurrence of apoptosis.

Free Research Field

医歯薬学