2017 Fiscal Year Final Research Report
Evaluation of organ remodeling in severe sepsis
Project/Area Number |
15K10985
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
|
Research Institution | University of Miyazaki |
Principal Investigator |
Yano Takeshi 宮崎大学, 医学部, 講師 (80521707)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 敗血症 |
Outline of Final Research Achievements |
Sepsis is a condition that exhibits organ dysfunction due to poor control of host biological response to infection. In recent years, multidisciplinary treatment based on effective guidelines has been applied, short-term treatment outcomes are improving, but as a result of prolonged systemic dysfunction, long-term prognosis remains poor. In this experiment, we investigated the suppression effect of the recombinant thrombomodulin (rTM), which has a strong anti-inflammatory effect, for the prolonged vascular dysfunction in sepsis, the suppression of vascular endothelial dysfunction, and the effect on the recovery phase. When rTM was added, there was a tendency to suppress the prolongation of vasoconstriction degradation caused by lipopolysaccharide (LPS). Although LPS strongly injured vascular endothelial cells, rTM showed a tendency to maintain the tissue structure without association in the occurrence of apoptosis.
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Free Research Field |
医歯薬学
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