2017 Fiscal Year Final Research Report
A clarify of a role of remote organ failure after tissue injury
| Project/Area Number |
15K10996
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
増野 智彦 日本医科大学, 医学部, 講師 (00318528)
松居 亮平 日本医科大学, 医学部, 助教 (50727865)
横田 裕行 日本医科大学, 医学部, 助教授 (60182698)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 骨軟部組織損傷 / 外傷後臓器障害 |
|---|
| Outline of Final Research Achievements |
We investigated the mechanism of inflammatory response after trauma using ''Two-hit model".
Two-hit model consists of tissue-bone matrix (TBX) model and hemorrhagic shock model. TBX model is a novel model, we developed before.
TBX induced a systematic inflammatory response and attenuated a intestinal motility at 21 hours after transplantation of TBX. However "Tow-hit model" did not induced inflammatory response in our experiment.
|
| Free Research Field |
外傷学
|
