Fundamental study on delivery system of DNA vaccine-embedded CPH nanoparticles for cancer prevention using oral mucosa

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11031
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: MAEDA HATSUHIKO 愛知学院大学, 歯学部, 教授 (30175591)
• Co-Investigator(Kenkyū-buntansha): 久保 勝俊 愛知学院大学, 歯学部, 准教授 (60329604)
• Co-Investigator(Renkei-kenkyūsha): SUGITA Yoshihiko 愛知学院大学, 歯学部, 准教授 (20367618) ; SATO Emiko 愛知学院大学, 歯学部, 講師 (60111001) ; YOSHIDA Waka 愛知学院大学, 歯学部, 講師 (10513210)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DNAワクチン / パピローマウイルス / ナノスフェアー / CPHナノ粒子 / テープストリッピング法 / ドラッグデリバリー / 口腔 / 癌抑制効果

Outline of Final Research Achievements

The delivery system of DNA vaccine-embedded hydrophobic pullulan nanoparticles (CPH nanoparticles) with tape stripping method using oral mucosa for cancer prevention, that associated papillomavirus infection, was studied.
As a result, it was suggested that DNA vaccine-embedded CPH nanoparticles with tape stripping method was useful for cancer prevention. Therefore, it contributes to the papillomavirus-induced oral cancer prevention.

Free Research Field

医歯薬学・歯学・形態系基礎歯学