2018 Fiscal Year Annual Research Report
Mechanisms of Rho family proteins during cartolage and bone formation
| Project/Area Number |
15K11051
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| Research Institution | Showa University |
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Principal Investigator |
山田 篤 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 細胞内シグナル伝達因子 |
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| Outline of Annual Research Achievements |
細胞内シグナル伝達因子で低分子量Gタンパク質であるRac1およびCdc42の機能の重複の研究のために、四肢間葉系幹細胞特異的および軟骨細胞特異的Rac1およびCdc42遺伝子ダブルコンディショナルノックアウトマウスの作製を行い、その表現型に関する研究を行なってきた。本年度は、これらの結果を論文にまとめた。
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[Journal Article] Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation.2018
Author(s)
Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, Nagayama K, Maki K, Yamamoto M, Kamijo R
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Journal Title
Sci. Rep.
Volume: 8
Pages: 10579
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cooperation of Rho family proteins Rac1 and Cdc42 in cartilage development and calcified tissue formation.2018
Author(s)
Ikehata M, Yamada A, Fujita K, Yoshida Y, Kato T, Sakashita A, Ogata H, Iijima T, Kuroda M, Chikazu D, Kamijo R
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Journal Title
Biochem Biophys Res Commun
Volume: 500
Pages: 525-529
DOI
Peer Reviewed / Int'l Joint Research
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