2017 Fiscal Year Final Research Report
Molecular mechanism of nerve regeneration and sensory disorder following axonal injury
Project/Area Number |
15K11057
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Nihon University |
Principal Investigator |
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Project Period (FY) |
2015-10-21 – 2018-03-31
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Keywords | 軸索損傷 / 神経回路 / 下歯槽神経 / 三叉神経脊髄路核 / ERK |
Outline of Final Research Achievements |
To study each process of anatomical, neurochemical and physiological regeneration after nerve injury, we developed a model of complete IAN transection (IANX) in mice. A subset of small TG neurons, i.e. C afferents, had re-innervated their appropriate receptive field within 2 weeks post-axotomy, and the peptidergic neurons regenerate more efficiently compared to non-peptidergic neurons after trigeminal nerve injury. On the other hand, head-withdrawal threshold (HWT) to noxious heat or pinch stimulation began to return toward basal level on day 14 after IANX, but did not recover completely. The distribution pattern of pinch stimuli-induced pERK-IR cells, i.e. second order neurons and/or interneurons, was altered in Vc at 2 weeks after IANX. We also found that the reduction in E-cadherin expression in Vc is correlated with increase of HWT to noxious stimuli after IANX.
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Free Research Field |
神経科学
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