Role of CCL2/CCL2 receptor signaling within trigeminal ganglia on the inflammatory pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Azabu University
• Principal Investigator: Takeda Mamoru 麻布大学, 生命・環境科学部, 教授 (20227036)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 三叉神経節 / ケモカイン / 炎症 / 痛覚過敏 / パッチクランプ / 免疫組織化学 / 逃避反射 / ＣＣＬ２

Outline of Final Research Achievements

This study investigated the functional significance of hyperalgesia in the CCL2/CCL2 receptor signaling system in trigeminal ganglion (TG) neurons following inflammation, using behavioral, immunohistochemical and electrophysiological analysis.The present study provides evidence that CCL2 enhances the excitability of small-diameter TG neurons following facial skin inflammation via the upregulation of CCL2/CCL2 receptor signaling. These findings suggest that ganglionic CCL2/CCL2 receptor signaling is a therapeutic molecular target for the treatment of trigeminal inflammatory hyperalgesia.

Free Research Field

医歯薬学