Does sympathetic nervous system regulate osteocyte function?

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: Kondo Hisataka 愛知学院大学, 歯学部, 講師 (40469002)
• Co-Investigator(Kenkyū-buntansha): 友寄 大介 (兒玉大介) 愛知学院大学, 薬学部, 講師 (40549979) ; 戸苅 彰史 愛知学院大学, 歯学部, 教授 (80126325) ; 平居 貴生 愛知学院大学, 薬学部, 准教授 (80389072) ; 浜村 和紀 愛知学院大学, 歯学部, 准教授 (00422767)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 骨代謝 / 骨細胞

Outline of Final Research Achievements

The osteocytes that are the most abundant in bone tissue control osteoclastic bone resorption through the expression of the receptor activator of NF-κB ligand (RANKL). We reported that sympathetic regulation of osteoblasts and osteoclasts. In this study, we examined whether osteocytes are involved in sympathetic regulation of bone metabolism. First, we confirmed that sympathetic neurons and osteocyte were functionally connected via α adrenergic receptor and noradrenaline influences RANKL production by osteocytes via the α adrenergic receptor. Thus, we suggested that the sympathetic nervous system directly controls RANKL expression of osteocytes and influences bone metabolism.

Free Research Field

骨代謝