2017 Fiscal Year Final Research Report
Analysis of mechanisms related to the induction of mucosal immunity in Peyer's patches against oral vaccine
| Project/Area Number |
15K11085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 経口ワクチン / 組換え型サルモネラ / 分泌型IgA / パイエル板 |
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| Outline of Final Research Achievements |
We assessed mechanisms of the induction of antigen (Ag)-specific intestinal secretory (S)IgA antibody (Ab) responses against orally administered vaccines in order to provide helpful information that will aid in the development of an effective mucosal vaccine. Our previous study showed that Peyer’s patches (PP) are required for the induction of Ag-specific intestinal SIgA Ab responses to oral attenuated recombinant Salmonella vaccine strain. In this study, we further showed that PP B cells play specific roles for the induction of Ag-specific mucosal IgA Ab responses in vitro.
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| Free Research Field |
感染免疫学
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