Elucidation of the salivary secretion regulation mechanism through mitochondrial function control by estrogen

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tsurumi University
• Principal Investigator: Nakayama Ryoko 鶴見大学, 歯学部, 助教 (50749843)
• Co-Investigator(Kenkyū-buntansha): 斎藤 一郎 鶴見大学, 歯学部, 教授 (60147634) ; 井上 裕子 日本薬科大学, 薬学部, 教授 (50367306) ; 梁 洪淵 鶴見大学, 歯学部, 講師 (10298268) ; 内田 仁司 鶴見大学, 歯学部, 学内講師 (20736996)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔乾燥症 / ドライマウス / 女性ホルモン / エストロゲン / ミトコンドリア / 唾液 / マウス / OVX

Outline of Final Research Achievements

In this study, in order to clarify the involvement of estrogen in salivary secretion ability and its molecular mechanism, early menopausal mice by OVX were analyzed as model animals. Salivary secretion decreased with OVX decrease of blood estrogen concentration, and model animal of xerostomia in menopause could be constructed. Furthermore, supplementation of estrogen improved the amount of saliva secretion and acinar shrinkage, and it was shown that estrogen is greatly related to the salivary secretion ability of the salivary glands. As a mechanism of this phenomenon, focusing on the control of mitochondrial function by estrogen, we analyzed mitochondrial function and others. As a result, it was suggested that a qualitative change in mitochondria, probably a change in morphology, accompanying the change in the amount of estrogen occurred.

Free Research Field

病態系口腔科学