Pathogenicity of OmpA-like protein of periodontopathic bacteria to the host cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K11094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Asahi University
• Principal Investigator: Megumi Inomata 朝日大学, 歯学部, 准教授 (40553798)
• Co-Investigator(Kenkyū-buntansha): 村上 幸孝 朝日大学, 歯学部, 教授 (60239506)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 歯周病関連細菌 / 自然免疫 / 血清抵抗性 / 糖修飾 / 外膜タンパク質

Outline of Final Research Achievements

Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf), which are representative periodontopathic bacteria, have OmpA-like proteins (OmpALPs) as outer-membrane proteins, but the involvement of OmpALPs in the pathogenicity has not been clarified. This research revealed that Pg-derived OmpALP is involved in serum resistance and host cell stimulation, and the sugar modification of Tf-derived OmpALP.

Free Research Field

口腔免疫学、口腔細菌学

Academic Significance and Societal Importance of the Research Achievements

本研究の実施によって、今まで理解されてこなかった歯周病関連細菌の有する主要な外膜蛋白質の宿主に及ぼす影響、すなわち病原性を明らかにすることができたと考える。得られた研究成果は、腸内細菌のOmpA蛋白質にも反映すると考えられるため、歯科医学のみならず、基礎医科学・生物学においても有益な知見となると思われる。