Development of a novel root caries treatment by bacterial inactivation factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: OHARA Naoko 岡山大学, 大学病院, 講師 (80301365)
• Co-Investigator(Kenkyū-buntansha): 吉山 昌宏 岡山大学, 医歯薬学総合研究科, 教授 (10201071) ; 大原 直也 岡山大学, 医歯薬学総合研究科, 教授 (70223930)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 根面う蝕 / う蝕誘発モデル / う蝕細菌

Outline of Final Research Achievements

In this study an in vitro root caries induction model system was constructed to develop a new treatment for inhibition of progression of root caries. Using this model system, we investigated the influence on root caries progression bacteria dynamics of the carious lesion by strains and the culture conditions of cariogenic bacteria. The results showed that three Actinomyces species, A. naeslundii, A. viscosus, and A. israelii, possessed different characteristics on the pathology and the mechanisms of root caries progression.

Free Research Field

歯科保存学