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2017 Fiscal Year Final Research Report

Development of hop beverages to control dental plaque

Research Project

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Project/Area Number 15K11125
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ODACHI Tatsuji  北海道医療大学, 歯学部, 助教 (60214152)

Co-Investigator(Kenkyū-buntansha) 川上 智史  北海道医療大学, 歯学部, 教授 (00169682)
舞田 健夫  北海道医療大学, 歯学部, 教授 (40229282)
安彦 善裕  北海道医療大学, 歯学部, 教授 (90260819)
齊藤 正人  北海道医療大学, 歯学部, 教授 (50337036)
植原 治  北海道医療大学, 歯学部, 助教 (00709248)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsホップ / キサントフモール
Outline of Final Research Achievements

Hops are safe for living bodies and have antimicrobial and anti-inflammatory effects on oral bacteria which cause dental plaque, and anti-dental plaque action can be expected by their combined action. However, there have been reports on antimicrobial activity against various gram-positive bacteria by components of hops, but how hops act on caries pathogenic bacteria S. mutans and periodontal pathogenic bacteria P. gingivalis There is no report. In this study, the influence of antibacterial component (xanthohumol) of hops on S. mutans, P. gingivalis and gingival epithelial cells was evaluated. It was suggested that xanthohumol could inhibit iron uptake necessary for the growth of P. gingivalis at a concentration not showing cytotoxicity to gingival epithelial cells.

Free Research Field

保存修復学

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Published: 2019-03-29  

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