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2017 Fiscal Year Final Research Report

Devalopment of antimicrobial technique utilizing photo-irradiated polyphenol for oral care

Research Project

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Project/Area Number 15K11144
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Keisuke Nakamura  東北大学, 歯学研究科, 講師 (30431589)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsポリフェノール / 殺菌 / 光照射
Outline of Final Research Achievements

In this project, in vitro and in vivo tests were performed to evaluate the antimicrobial chemotherapy utilizing photo-irradiated polyphenols. Streptococcus mutans biofilm was treated with the technique using caffeic acid, chlorogenic acid and proanthocyanidin as a representative polyphenol. The results showed that the technique using caffeic acid exerted the highest bactericidal activity. In vivo study where oral mucosal irritation potential of the antimicrobial technique was evaluated demonstrated that it exerted slight irritation potential. Therefore, in order to apply this technique to clinical dentistry, it is suggested that future studies should evaluate the bactericidal effect (benefit) and the oral mucosal irritation potential (risk) more in detail.

Free Research Field

歯科補綴学

URL: 

Published: 2019-03-29  

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