Investigation of inhibitors for bone resorption caused by excess occlusal load

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu University
• Principal Investigator: MAKHIRA Seicho 九州大学, 歯学研究院, 准教授 (80304450)
• Co-Investigator(Kenkyū-buntansha): 峯 裕一 九州大学, 医学研究院, 講師 (60605989) ; 諸井 亮司 九州大学, 大学病院, 助教 (70325471) ; 篠原 義憲 九州大学, 歯学研究院, 共同研究員 (00423533)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メカニカルストレス / ephrin / Eph / 圧縮

Outline of Final Research Achievements

The communication between ephrin/Eph family was recently shown to be involved in cell differentiation under mechanical stress. To understand the roles of ephrinB2 and EphB4 in alveolar bone under initial mechanical stress of dental implant replacement, in vivo experiment was carried out. The mini-implant surface immobilised with ephrinB2-Fc recovered the suppression of Osterix. Taken together, the present results suggest that increased binding of ephrinB2 and EphB4 in osteoblast cells exposed to initial mechanical force, especially compressive force, may be involved in alveolar bone recovery.

Free Research Field

歯科補綴学