Comprehensive analysis of salivary metabolites and establishment of new therapies in oral candidiasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K11178
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kanagawa Dental College
• Principal Investigator: HOSHI NORIYUKI 神奈川歯科大学, 大学院歯学研究科, 准教授 (20339782)
• Co-Investigator(Kenkyū-buntansha): 杉本 昌弘 慶應義塾大学, その他の研究科, 講師 (30458963) ; 木本 克彦 神奈川歯科大学, 大学院歯学研究科, 教授 (70205011)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 唾液 / メタボローム解析 / 口腔不快症状 / 口腔カンジダ症

Outline of Final Research Achievements

Oral candidiasis is a common disease among the elderly.Various symptoms of oral　discomfort decrease a patient’s quality of life.Oral candidiasis has a high　recurrence rate and responds poorly to treatments.Patients mainly receive therapeutic countermeasures.This study treated oral candidiasis by increasing the volume of saliva with an occlusal chewing treatment described previously.Salivary metabolites were comprehensively analyzed in order to identify the salivary components involved in oral candidiasis.We conducted a fundamental study on the safe treatment of oral candidiasis.

Free Research Field

歯科補綴